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Regulon information related genes

Regulon information related genes

Locus ID TAIR Annotation Gene Name Regulon Subcellular Location PPDB Location TargetP Predicted SubcellLoc BLink PFAM Uni-PROT GO Cellular Component GO Molecular Function GO Biological Process MetNet Pathways MetNet Comments References
AT1G52340

ABA DEFICIENT 2 (ABA2)
CONTAINS InterPro DOMAIN/s: NAD(P)-binding domain (InterPro:IPR016040), Glucose/ribitol dehydrogenase (InterPro:IPR002347), Short-chain dehydrogenase/reductase SDR (InterPro:IPR002198)
BEST Arabidopsis thaliana protein match is: NAD(P)-binding Rossmann-fold superfamily protein (TAIR:AT3G51680.1)
Has 120353 Blast hits to 120130 proteins in 3578 species: Archae - 983
Bacteria - 78428
Metazoa - 5777
Fungi - 6239
Plants - 2770
Viruses - 5
Other Eukaryotes - 26151 (source: NCBI BLink).

NAD(P)-binding Rossmann-fold superfamily protein;
SUBAPPDB; gi|15218213;
adh_short;
Q9C826;

The Arabidopsis thaliana ABA2 gene was initially studied through the biochemical characterization of several aba mutant alleles;

The study of aba2-1 in particular reported a biosynthetic defect in the conversion of xanthoxin to abscisic acid (ABA) |CITS:[9159947]|;

However, the authors of this study were not able to clearly define whether ABA2 was the only enzyme involved in the three-step catalytic conversion;

In a later study, ABA2 was recombinantly expressed in E.coli where it was shown to catalyze the NAD-dependent conversion of xanthoxin to abscisic aldehyde |CITS:[12172025]|;

In the same study, ABA2 was shown to be consitutively expressed throughout the plant and to not be upregulated in response to osmotic stress.::The aba2 mutant in Arabidopsis is the only known mutant for the conversion of xanthoxin to ABA aldehyde;

The gene has not been cloned.

AT1G16540

ABA DEFICIENT 3 (ABA3)
CONTAINS InterPro DOMAIN/s: Pyridoxal phosphate-dependent transferase, major domain (InterPro:IPR015424), MOSC, N-terminal beta barrel (InterPro:IPR005303), Aminotransferase, class V/Cysteine desulfurase (InterPro:IPR000192), Molybdenum cofactor sulfurase, C-terminal (InterPro:IPR005302), Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (InterPro:IPR015421)
BEST Arabidopsis thaliana protein match is: Molybdenum cofactor sulfurase family protein (TAIR:AT1G30910.1)
Has 7940 Blast hits to 7904 proteins in 1914 species: Archae - 94
Bacteria - 5396
Metazoa - 390
Fungi - 394
Plants - 292
Viruses - 1
Other Eukaryotes - 1373 (source: NCBI BLink).

molybdenum cofactor sulfurase (LOS5) (ABA3);
SUBAPPDB; gi|18394375;
MOSC;
Aminotran_5;
MOSC_N;
Q9C5X8;

Mutant in Arabidopsis;

Gene has not been cloned.::NIL The activation of plant enzymes such as aldehyde oxidase (AO) and xanthine dehydrogenase (XDH) depends on the sulfo-form of molybdenum cofactor (moco);

The sulfuration of moco is catalyzed by moco sulfurase (ABA3) that converts the dioxo-molybdenum center of the protein to a monooxo/monosulfur-molybdenum center;

Moco sulfurase, isolated and cloned from Arabidopsis thaliana, is a two-domain protein that possesses an N-terminal ABA3-NifS domain expressing pyridoxal phosphate (PLP)-dependent sulfurase activity and a C-terminal domain probably involved in recognizing target enzymes and posttranslational activation of ABA3 |CITS: [11553608]|;

The NifS domain of moco sulfurase binds PTP cofactor generating a enzyme-bound persulfide intermediate that results from the desulfuration of cysteine;

Other than comparable NifS-like proteins the donor sulfur is not used for the formation of [Fe-S] cluster assembly but transferred to moco itself;

It appears that ABA3 forms homodimer mediated by ABA3-NifS which allows mobilizing of two sulfurs for the dimeric target enzymes AO and XDH |CITS: [15561708]|;

Moco sulfurase (ABA3) seems to be ubiquitously expressed in plants, the expression being strongly enhanced in response to drought, salt or abscisic acid (ABA) treatment |CITS: [11549764]|.::The activation of plant enzymes such as aldehyde oxidase (AO) and xanthine dehydrogenase (XDH) depends on the sulfo-form of molybdenum cofactor (moco);

The sulfuration of moco is catalyzed by moco sulfurase (ABA3) that converts the dioxo-molybdenum center of the protein to a monooxo/monosulfur-molybdenum center;

Moco sulfurase, isolated and cloned from Arabidopsis thaliana, is a two-domain protein that possesses an N-terminal ABA3-NifS domain expressing pyridoxal phosphate (PLP)-dependent sulfurase activity and a C-terminal domain probably involved in recognizing target enzymes and posttranslational activation of ABA3 |CITS: [11553608]|;

The NifS domain of moco sulfurase binds PTP cofactor generating a enzyme-bound persulfide intermediate that results from the desulfuration of cysteine;

Other than comparable NifS-like proteins the donor sulfur is not used for the formation of [Fe-S] cluster assembly but transferred to moco itself;

It appears that ABA3 forms homodimer mediated by ABA3-NifS which allows mobilizing of two sulfurs for the dimeric target enzymes AO and XDH |CITS: [15561708]|;

Moco sulfurase (ABA3) seems to be ubiquitously expressed in plants, the expression being strongly enhanced in response to drought, salt or abscisic acid (ABA) treatment |CITS: [11549764]|;

In vitro experiments suggest that this enzyme can also catalyze the decomposition of L-selenocysteine, however, this compound is not expected to be a natural substrate for this enzyme |CITS: [15561708]|.

AT5G64740

cellulose synthase 6 (CESA6)
FUNCTIONS IN: cellulose synthase activity, transferase activity, transferring glycosyl groups
INVOLVED IN: in 6 processes
LOCATED IN: cortical microtubule, transverse to long axis, Golgi apparatus, cellulose synthase complex, plasma membrane, membrane
EXPRESSED IN: 25 plant structures
EXPRESSED DURING: 15 growth stages
CONTAINS InterPro DOMAIN/s: Cellulose synthase (InterPro:IPR005150), Zinc finger, RING-type (InterPro:IPR001841)
BEST Arabidopsis thaliana protein match is: cellulose synthase 5 (TAIR:AT5G09870.1)
Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0
Bacteria - 0
Metazoa - 736
Fungi - 347
Plants - 385
Viruses - 0
Other Eukaryotes - 339 (source: NCBI BLink).

cellulose synthase 6;
121SUBAPPDB; gi|15238231;
Cellulose_synt;
Q94JQ6;

Mutant phenotype suggesting this cellulose synthase isoform is involved in the primary cell wall cellulose synthesis.

AT3G15850

fatty acid desaturase 5 (FAD5)
CONTAINS InterPro DOMAIN/s: Fatty acid desaturase, type 1, core (InterPro:IPR015876), Fatty acid desaturase, type 1 (InterPro:IPR005804)
BEST Arabidopsis thaliana protein match is: Fatty acid desaturase family protein (TAIR:AT3G15870.1)
Has 3424 Blast hits to 3424 proteins in 822 species: Archae - 0
Bacteria - 1534
Metazoa - 801
Fungi - 236
Plants - 106
Viruses - 4
Other Eukaryotes - 743 (source: NCBI BLink).

fatty acid desaturase 5;
2 - photosynthesisSUBAPPDB;Chloroplast (C)gi|18400926;
FA_desaturase;
Q949X0;

AT4G30950

fatty acid desaturase 6 (FAD6)
FUNCTIONS IN: omega-6 fatty acid desaturase activity
INVOLVED IN: photoinhibition, fatty acid biosynthetic process
LOCATED IN: chloroplast, chloroplast envelope
EXPRESSED IN: 22 plant structures
EXPRESSED DURING: 13 growth stages
CONTAINS InterPro DOMAIN/s: Fatty acid desaturase, type 1 (InterPro:IPR005804)
BEST Arabidopsis thaliana protein match is: fatty acid desaturase 8 (TAIR:AT5G05580.1)
Has 3227 Blast hits to 3218 proteins in 733 species: Archae - 0
Bacteria - 1371
Metazoa - 67
Fungi - 380
Plants - 896
Viruses - 0
Other Eukaryotes - 513 (source: NCBI BLink).

fatty acid desaturase 6;
2 - photosynthesisSUBAPPDB;Chloroplast (C)gi|15235766;
FA_desaturase;
P46312;

The protein location information is from ppdb database

AT4G23100

glutamate-cysteine ligase (GSH1)
FUNCTIONS IN: glutamate-cysteine ligase activity
INVOLVED IN: in 13 processes
LOCATED IN: chloroplast stroma, chloroplast
EXPRESSED IN: 23 plant structures
EXPRESSED DURING: 14 growth stages
CONTAINS InterPro DOMAIN/s: Glutamate--cysteine ligase, GCS2 (InterPro:IPR006336), Glutamate--cysteine ligase, plant (InterPro:IPR011556)
Has 2650 Blast hits to 2650 proteins in 482 species: Archae - 15
Bacteria - 892
Metazoa - 0
Fungi - 0
Plants - 118
Viruses - 0
Other Eukaryotes - 1625 (source: NCBI BLink).
ROOT MERISTEMLESS 1 (RML1)
FUNCTIONS IN: glutamate-cysteine ligase activity
INVOLVED IN: in 13 processes
LOCATED IN: chloroplast
EXPRESSED IN: 23 plant structures
EXPRESSED DURING: 14 growth stages
CONTAINS InterPro DOMAIN/s: Glutamate--cysteine ligase, GCS2 (InterPro:IPR006336), Glutamate--cysteine ligase, plant (InterPro:IPR011556)
Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798
Bacteria - 22429
Metazoa - 974
Fungi - 991
Plants - 531
Viruses - 0
Other Eukaryotes - 9610 (source: NCBI BLink).
glutamate-cysteine ligase (GSH1)
CONTAINS InterPro DOMAIN/s: Glutamate--cysteine ligase, GCS2 (InterPro:IPR006336), Glutamate--cysteine ligase, plant (InterPro:IPR011556).

glutamate-cysteine ligase;
SUBAPPDB; gi|15236390;
gi|79325233;
gi|334186834;
GCS2;
P46309;

NIL The enzyme catalyzing the first step in the glutathione biosynthesis, i.e;

glutamate-cysteine ligase has been isolated from Arabidopsis thaliana |CITS: [MAY94]|;

This step has been discussed as the rate-limiting step of the glutathione biosynthesis |CITS: [1112810]|;

The protein was recombinant expressed in E;

coli
and its molecular function of catalyzing the ATP-dependent formation of the dipeptide gamma-glutamylcysteine from cysteine and glutamate demonstrated;

The kinetic mechanism of the reaction has been described to fit a ter-reactant kinetic mechanism displaying a preferred order of substrate addition;

The regulation of the enzyme appears to differ from other related eukaryotic enzymes as it undergoes a conformational change that causes modified activities in response to redox conditions and is not associated with a regulatory subunit being reported from mammalian enzymes |CITS: [15180996]|.::The enzyme catalyzing the first step in the glutathione biosynthesis, i.e;

glutamate-cysteine ligase has been isolated from Arabidopsis thaliana |CITS: [MAY94]|;

This step has been discussed as the rate-limiting step of the glutathione biosynthesis |CITS: [1112810]|;

The protein was recombinant expressed in E;

coli
and its molecular function of catalyzing the ATP-dependent formation of the dipeptide γ-glutamylcysteine from cysteine and glutamate demonstrated;

The kinetic mechanism of the reaction has been described to fit a ter-reactant kinetic mechanism displaying a preferred order of substrate addition;

The regulation of the enzyme appears to differ from other related eukaryotic enzymes as it undergoes a conformational change that causes modified activities in response to redox conditions and is not associated with a regulatory subunit being reported from mammalian enzymes |CITS: [15180996]|.::The protein location information is from plprot database

AT3G52430

PHYTOALEXIN DEFICIENT 4 (PAD4)
CONTAINS InterPro DOMAIN/s: Lipase, class 3 (InterPro:IPR002921)
BEST Arabidopsis thaliana protein match is: senescence-associated gene 101 (TAIR:AT5G14930.2)
Has 722 Blast hits to 622 proteins in 73 species: Archae - 0
Bacteria - 23
Metazoa - 17
Fungi - 11
Plants - 620
Viruses - 1
Other Eukaryotes - 50 (source: NCBI BLink).

alpha/beta-Hydrolases superfamily protein;
80SUBAPPDB; gi|15231218;
Lipase_3;
Q9S745;

PUBMED:10557364;
PUBMED:10796016;
PUBMED:10972893;
PUBMED:11041879;
PUBMED:11114160;
PUBMED:11277440;
PUBMED:11387977;
PUBMED:11439127;
PUBMED:11574472;
PUBMED:11595797;
PUBMED:11826312;
PUBMED:11846877;
PUBMED:11850411;
PUBMED:11950980;
PUBMED:12059109;
PUBMED:12068100;
PUBMED:12236603;
PUBMED:12410815;
PUBMED:12609045;
PUBMED:12694596;
PUBMED:12795697;
PUBMED:12805591;
PUBMED:12848825;
PUBMED:14576290;
PUBMED:14600834;
PUBMED:14617091;
PUBMED:14675428;
PUBMED:15242165;
PUBMED:15242170;
PUBMED:15347794;
PUBMED:15447647;
PUBMED:15546349;
PUBMED:15728340;
PUBMED:15773856;
PUBMED:15828688;
PUBMED:15894742;
PUBMED:15923348;
PUBMED:16040633;
PUBMED:16146526;
PUBMED:16167903;
PUBMED:16212604;
PUBMED:16299172;
PUBMED:16306139;
PUBMED:16353557;
PUBMED:16367962;
PUBMED:16461580;
PUBMED:16531493;
PUBMED:16813576;
PUBMED:8725243;
PUBMED:9136026;
PUBMED:9634589;
PUBMED:9881167;
TAIR:58;
TAIR:462;
TAIR:1021;
TAIR:1865;
TAIR:2482;
TAIR:3294;
TAIR:3858;
TAIR:5809;
TAIR:5950;
TAIR:1545963;
TAIR:1545980;
TAIR:1546537;
TAIR:1546581;
TAIR:1546810;
TAIR:1546824;
TAIR:1546827;
TAIR:1546848;
TAIR:1546861;
TAIR:1547288;
TAIR:1547292;
TAIR:501680062;
TAIR:501680226;
TAIR:501680386;
TAIR:501681354;
TAIR:501681561;
TAIR:501681583;
TAIR:501681961;
TAIR:501682207;
TAIR:501682572;
TAIR:501683629;
TAIR:501706975;
TAIR:501707006;
TAIR:501707568;
TAIR:501707595;
TAIR:501707722;
TAIR:501708307;
TAIR:501708813;
TAIR:501708849;
TAIR:501709027;
TAIR:501709183;
TAIR:501709187;
TAIR:501709189;
TAIR:501709198;
TAIR:501709212;
TAIR:501709235;
TAIR:501709638;
TAIR:501709663;
TAIR:501710450;
TAIR:501711226;
TAIR:501711422;
TAIR:501711480;
TAIR:501711636;
TAIR:501712916;
TAIR:501712918;
TAIR:501713147;
TAIR:501713263;
TAIR:501713701;
TAIR:501713778;
TAIR:501713785;
TAIR:501713801;
TAIR:501713805;
TAIR:501714741;
TAIR:501714819;
TAIR:501715007;
TAIR:501715020;
TAIR:501716518;
TAIR:501716526;
TAIR:501717117;
TAIR:501717134;
TAIR:501717147;
TAIR:501717288;
TAIR:501717546;
TAIR:501717706;
TAIR:501717935;
TAIR:501718019;
TAIR:501718041;
TAIR:501718183;
TAIR:501718241;
TAIR:501718575;
TAIR:501718734;
TAIR:501719013;
TAIR:501719292;
TAIR:501719350;
TAIR:501720196;
TAIR:501720524;
TAIR:501720526;
TAIR:501720591;
TAIR:501720697;
TAIR:501720944;
TAIR:501721402;
TAIR:501721410;
TAIR:501721438;
TAIR:501721979;
TAIR:501722485;
TAIR:501722734;
TAIR:501722872;
TAIR:501723426;
TAIR:501723825;
TAIR:501724161;
TAIR:501724206;
TAIR:501724593;
TAIR:501724638;
TAIR:501724822;
TAIR:501725098;
TAIR:501727266;
TAIR:501727344;
TAIR:501728745;
TAIR:501728994;
TAIR:501729207;
TAIR:501729389;
TAIR:501729422;
TAIR:501729561;
TAIR:501729863;
TAIR:501730253;
TAIR:501732269;
TAIR:501733889;
TAIR:501734211;
TAIR:501734212;
TAIR:501735320;
TAIR:501735504;
TAIR:501736272;
TAIR:501736818;
TAIR:501736988;
TAIR:501737034;
TAIR:501737966;
TAIR:501737992;
TAIR:501738108;
TAIR:501739780;
TAIR:501739991;
TAIR:501740203;
TAIR:501741272;
TAIR:501741843;
TAIR:501742046;
TAIR:501742642;
TAIR:501742857;
TAIR:501743092;
TAIR:501745247;
TAIR:501745789;
TAIR:501745822;
TAIR:501746404;
TAIR:501747012;
TAIR:501747398;
TAIR:501747623;
TAIR:501748054;
TAIR:501748147;
TAIR:501748991;
TAIR:501750086;
TAIR:501750548;
TAIR:501751107;
TAIR:501751436;
TAIR:501753039;
TAIR:501753209;
TAIR:501753242;
TAIR:501753499;

AT1G56650

production of anthocyanin pigment 1 (PAP1)
CONTAINS InterPro DOMAIN/s: SANT, DNA-binding (InterPro:IPR001005), Homeodomain-like (InterPro:IPR009057), Myb, DNA-binding (InterPro:IPR014778), HTH transcriptional regulator, Myb-type, DNA-binding (InterPro:IPR017930), Homeodomain-related (InterPro:IPR012287), Myb transcription factor (InterPro:IPR015495)
BEST Arabidopsis thaliana protein match is: myb domain protein 90 (TAIR:AT1G66390.1)
Has 8761 Blast hits to 8206 proteins in 539 species: Archae - 0
Bacteria - 0
Metazoa - 765
Fungi - 472
Plants - 5883
Viruses - 3
Other Eukaryotes - 1638 (source: NCBI BLink).

production of anthocyanin pigment 1;
164SUBAPPDB; gi|15223582;
Myb_DNA-binding;
Q9FE25;